ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway
نویسندگان
چکیده
منابع مشابه
Effects of HIIT and Curcumin Supplementation on Rat Cardiac Fibrosis Signaling Pathway Following Myocardial Infraction
Background and Objective: the aim was to investigate the effects of 12 weeks of High Intensity Interval Training (HIIT) and curcumin supplementation on expression levels of FSTL1 and Smad7 and also Type I, III and IV collagens in rat model with myocardial infraction (MI). Methodology: 48 male rats were randomized into five groups of Reference, HIIT, Curcumin, Concomitant (HIIT+ Curcumin) and Co...
متن کاملActivation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway.
Sirtuins [sirtuin (SIRT)1-SIRT7] mediate the longevity-promoting effects of calorie restriction in yeast, worms, flies, and mice. Additionally, SIRT3 is the only SIRT analog whose increased expression has been shown to be associated with longevity in humans. The polyphenol resveratrol (RSV) is the first compound discovered able to mimic calorie restriction by stimulating SIRTs. In the present s...
متن کاملRelaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]
[This corrects the article on p. 4599 in vol. 9.].
متن کاملMir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7.
BACKGROUND/AIMS Cardiac fibrosis after myocardial infarction (MI) has been identified as an important factor in the deterioration of heart function. Previous studies have demonstrated that miR-21 plays an important role in various pathophysiological processes in the heart. However, the role of miR-21 in fibrosis regulation after MI remains unclear. METHODS To induce cardiac infarction, the le...
متن کاملMicroRNA-24 regulates cardiac fibrosis after myocardial infarction
Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure. Although dysregulation of microRNA (miRNA) is involved in various pathophysiological processes in the heart, the role of miRNA in fibrosis regulation after MI is not clear. Previously we observed the correlation between fibrosis and the miR-24 expression in hypertrophic hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-02585-4